Hollywood is a large neighborhood in Los Angeles and a major location in L.A. Noire. During the timeline that the game is set, Hollywood was in the midst of its "golden era" as a major setting for the movie industry, attracting movie producers and aspiring actors from the all over world. It was also the stage for some of the most notorious crimes in the 1940s, crimes that Detective Cole Phelps tries to solve while working for the LAPD. Hollywood is located north of the Wilshire District and is the northwesternmost point on the game map.
The Hollywoodland Sign overlooks the neighborhood. In 1947 the sign spelled out "Hollywoodland" as it was originally a promotion for a planned community in the 1920s. In 1949, two years after the events of L.A. Noire, the word "land" was removed from the sign. In 1978, the original sign was replaced with a new sign.
Hollywood contains one known subdistrict or neighborhood: Melrose.
- "The Black Caesar" - Yucca St. Apartment, The Black Caesar Food Hut, Ivar Ave., Jermaine Jones Musical Booking Agency, Numbers Operation run by Merlon Ottie, Ramez Removals, and the Polar Bear Ice Company.
- "The Set Up" - American Legion Boxing Stadium, Hotel El Mar Flophouse, Aleve Motel, alleyways through Hollywood, Thrifty Liquor Bookmakers, Examiner Drugstore Bookmakers, Ray's Bookmakers, the Hollywood Interstate Bus Depot, and the Egyptian Theatre.
- "Manifest Destiny" - The 111 Club, the Hollywood Police Station, The Blue Room, Elsa Lichtmann's Apartment, the Mocambo Club, Bus Stop shooting at 1384 N. Bronson Ave., Jack Kelso's Apartment, Robert's Diner, alleyway crime scene, Hollywood Post Office, Grauman's Chinese Theatre, and the alleway meeting place.